7-(Benzyloxy)-1-(2-methoxyethyl)-N,N,2-trimethyl-1H-benzimidazole-5-carboxamide → 7-Hydroxy-1-(2-methoxyethyl)-N,N,2-trimethyl-1H-benzimidazole-5-carboxamide

HRID 1258464노트

반응식

HRID 1258464 반응식
C([O:8][C:9]1[C:14]2[N:15]([CH2:19][CH2:20][O:21][CH3:22])[C:16]([CH3:18])=[N:17][C:13]=2[CH:12]=[C:11]([C:23]([N:25]([CH3:27])[CH3:26])=[O:24])[CH:10]=1)C1C=CC=CC=1>C(O)C.[C].[Pd]>[OH:8][C:9]1[C:14]2[N:15]([CH2:19][CH2:20][O:21][CH3:22])[C:16]([CH3:18])=[N:17][C:13]=2[CH:12]=[C:11]([C:23]([N:25]([CH3:27])[CH3:26])=[O:24])[CH:10]=1

참가 물질

4

반응물 1

HCID 672195137-(Benzyloxy)-1-(2-methoxyethyl)-N,N,2-trimethyl-1H-benzimidazole-5-carboxamide

생성물 1

HCID 672205657-Hydroxy-1-(2-methoxyethyl)-N,N,2-trimethyl-1H-benzimidazole-5-carboxamide수율 95.5%

시약·촉매·용매 2

HCID 178418390HCID 178418390, 화합물촉매HCID 702Ethanol용매

실험 절차

A mixture of 7-(benzyloxy)-1-(2-methoxyethyl)-N,N,2-trimethyl-1H-benzimidazole-5-carboxamide (483 mg, 1.31 mmol, Step 1) and 10% palladium-carbon (50 mg) in ethanol (30 mL) was stirred under hydrogen gas for 19 hours. The resulting mixture was filtered through a pad of Celite, and the filtrate was concentrated in vacuo to afford the title compound as a white solid (347 mg, 95%).

후처리

  1. filtrationThe resulting mixture was filtered through a pad of Celite
  2. concentrationthe filtrate was concentrated in vacuo

출처 및 근거

ORD 기록
ord-cd9460dcdc2e4ec09633ff2edc89949b
출처 데이터셋
uspto-grants-2013_06
특허 번호
US08466166B2

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