Ammonia → 3-Amino-4-chloro-2-fluoro-benzamide

HRID 1258685노트

반응식

[NH2:1][C:2]1[C:3]([F:12])=[C:4]([CH:8]=[CH:9][C:10]=1[Cl:11])[C:5](O)=[O:6].ClC([N:18](C)C)=C(C)C.N>>[NH2:1][C:2]1[C:3]([F:12])=[C:4]([CH:8]=[CH:9][C:10]=1[Cl:11])[C:5]([NH2:18])=[O:6]

참가 물질

반응물 3

HCID 222Ammonia

HCID 6407921-Chloro-N,N-2-trimethylpropenylamine

HCID 667650743-Amino-4-chloro-2-fluorobenzoic acid

생성물 1

HCID 667651113-Amino-4-chloro-2-fluoro-benzamide수율 69%

실험 절차

The sub-title compound was prepared from 3-amino-4-chloro-2-fluoro-benzoic acid, (1-chloro-2-methyl-propenyl)-dimethyl-amine and conc. NH3 in analogy to step 5c.

출처 및 근거

ORD 기록: ord-24c301b20feb4a0dbbd00baa8a1c45a2
출처 데이터셋: uspto-grants-2013_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08466186B2

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