참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Methylamine | HCID 6329 | — |
| 반응물 | 2,3,4,5-Tetrafluoronitrobenzene | HCID 79691 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 2,3,4-Trifluoro-N-methyl-6-nitroaniline | HCID 86674338 | — |
반응 단계
A solution of MeNH2 in THF (50.7 mL, 2 M, 101 mmol) was added dropwise to a solution of 1,2,3,4-tetrafluoro-5-nitrobenzene (9.88 g, 50.7 mmol) in THF (200 mL) at −20° C. The mixture was stirred at −20° C. for 1.5 h, concentrated, washed with brine and extracted with EtOAc. The organic layer was dried over Na2SO4, filtered and concentrated. Crystallization from EtOAc/PE gave the sub-title compound. Yield: 8.5 g (81%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08466186B2 |
|---|
| 출처 데이터셋 | uspto-grants-2013_06 |
|---|
| ORD ID | ord-e60785a33adb427683e16197dd93d862 |
|---|
| 출처 메모 | uspto-grants-2013_06 |
|---|
