Ammonia → HCID 67959596, 화합물

HRID 1258711노트

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HRID 1258711 반응식
[F:1][C:2]1[C:9](F)=[CH:8][C:5]([NH:6][CH3:7])=[C:4]([N+:11]([O-:13])=[O:12])[CH:3]=1.Cl.[F:15][C:16]([F:24])([F:23])[CH:17]1[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]1.C([O-])([O-])=O.[K+].[K+].N>CN(C=O)C>[F:1][C:2]1[C:9]([N:20]2[CH2:21][CH2:22][CH:17]([C:16]([F:24])([F:23])[F:15])[CH2:18][CH2:19]2)=[CH:8][C:5]([NH:6][CH3:7])=[C:4]([N+:11]([O-:13])=[O:12])[CH:3]=1

참가 물질

6

반응물 4

HCID 222AmmoniaHCID 11430Potassium CarbonateHCID 162181604-(Trifluoromethyl)piperidine hydrochlorideHCID 22615011HCID 22615011, 화합물

생성물 1

HCID 67959596HCID 67959596, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

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온도
40 °C

실험 절차

A mixture of 4,5-difluoro-N-methyl-2-nitroaniline (1.0 g, 5.3 mmol), 4-trifluoromethylpiperidine hydrochloride (2.02 g, 10.6 mmol), K2CO3 (1.47 g, 10.6 mmol) and DMF (7 mL) was stirred at 40° C. overnight under Ar atmosphere. The mixture was poured into aqueous ammonia and extracted with EtOAc. The organic layer was dried over Na2SO4, filtered and concentrated. The residue was washed with Et2O/PE to give the sub-title compound.

후처리

  1. extractionextracted with EtOAc
  2. dry with materialThe organic layer was dried over Na2SO4
  3. filtrationfiltered
  4. concentrationconcentrated
  5. washThe residue was washed with Et2O/PE

출처 및 근거

ORD 기록
ord-46108802bafd43518530964a9025a56f
출처 데이터셋
uspto-grants-2013_06
특허 번호
US08466186B2

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