2-Chloro-N-(2-hydroxyethyl)-5-nitro-benzenesulfonamide → 3-amino-N-(2-hydroxyethyl)benzenesulfonamide

HRID 1259045노트

반응식

HRID 1259045 반응식
Cl[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-])=O)=[CH:4][C:3]=1[S:11]([NH:14][CH2:15][CH2:16][OH:17])(=[O:13])=[O:12]>CO.[Pd]>[NH2:8][C:5]1[CH:4]=[C:3]([S:11]([NH:14][CH2:15][CH2:16][OH:17])(=[O:13])=[O:12])[CH:2]=[CH:7][CH:6]=1

참가 물질

4

반응물 1

HCID 145740892-Chloro-N-(2-hydroxyethyl)-5-nitro-benzenesulfonamide

생성물 1

HCID 4587823-amino-N-(2-hydroxyethyl)benzenesulfonamide수율 100%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

2-Chloro-N-(2-hydroxyethyl)-5-nitro-benzenesulfonamide (1.00 g, 3.57 mmol) was dissolved in methanol (35 ml) and placed under an atmosphere of nitrogen prior to the addition of 10% Pd/C (10 Wt %, 100 mg) in one portion. The reaction was evacuated, placed under an atmosphere of hydrogen (1 bar) and stirred vigorously overnight. The reaction was filtered through celite and the filtrate was concentrated in vacuo to afford the named product (0.77 g, 100%); LCMS Rt=1.44 min, m/z (ES+) 217 (M+H).

후처리

  1. customThe reaction was evacuated
  2. filtrationThe reaction was filtered through celite
  3. concentrationthe filtrate was concentrated in vacuo

출처 및 근거

ORD 기록
ord-98e97ed5a858492589e1c3ff766b0a92
출처 데이터셋
uspto-grants-2013_06
특허 번호
US08466201B2

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