Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
m-Chloroperbenzoic acid → 3-(benzyloxy)-5-bromopyridine N-oxide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | m-Chloroperbenzoic acid | HCID 70297 | — |
| 반응물 | 3-(Benzyloxy)-5-bromopyridine | HCID 15389198 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 3-(benzyloxy)-5-bromopyridine N-oxide | HCID 58213489 | — |
반응 단계
A solution of 3-(benzyloxy)-5-bromopyridine (from step 1) (1.0 eq.) and meta-chloroperbenzoic acid (mCPBA) (4.0 eq.) in dichloromethane (0.1 M) was stirred at room temperature for 18 hours. The reaction was quenched with saturated aqueous NaHCO3 solution and extracted with dichloromethane three times. The combined organic layers were dried over anhydrous MgSO4 and concentrated en vacuo. The crude residue was purified by a COMBIFLASH® system (ISCO) using 0-100% ethyl acetate in hexane to give 3-(benzyloxy)-5-bromopyridine 1-oxide.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08466167B2 |
| 출처 데이터셋 | uspto-grants-2013_06 |
| ORD ID | ord-ffcc0f99ca19412cb283d8b33d0bbc84 |
| 출처 메모 | uspto-grants-2013_06 |