HCID 69044992, 화합물 → HCID 69043464, 화합물
반응식
[O:1]=[C:2]1[C:11]2[CH2:10][CH2:9][CH2:8][CH2:7][C:6]=2[C:5]([CH2:12][CH:13]2[CH2:18][N:17](C(OCC3C=CC=CC=3)=O)[CH2:16][CH2:15][N:14]2[C:29]([O:31][C:32]([CH3:35])([CH3:34])[CH3:33])=[O:30])=[N:4][NH:3]1>O1CCCC1.[Pd]>[O:1]=[C:2]1[C:11]2[CH2:10][CH2:9][CH2:8][CH2:7][C:6]=2[C:5]([CH2:12][CH:13]2[CH2:18][NH:17][CH2:16][CH2:15][N:14]2[C:29]([O:31][C:32]([CH3:35])([CH3:34])[CH3:33])=[O:30])=[N:4][NH:3]1참가 물질
4
실험 절차
A solution of EXAMPLE 257D (0.77 g, 1.6 mmol) in tetrahydrofuran (100 ml) was treated with 10% palladium on carbon (85 mg, 0.8 mmol) at room temperature under hydrogen (balloon) overnight. The catalyst was removed by filtration, and the filtrate was concentrated. The residue was purified by flash chromatography (0-15% gradient of methanol in CH2Cl2) to provide the title compound. MS (DCI/NH3) m/z 349 (M+H)+.