Iodine → 4-hydroxy-3-methoxy-2-nitrobenzonitrile

HRID 1259512노트

반응식

HRID 1259512 반응식
[OH:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=O)=[C:4]([N+:10]([O-:12])=[O:11])[C:3]=1[O:13][CH3:14].[OH-].[NH4+:16].II>C1COCC1>[OH:1][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:16])=[C:4]([N+:10]([O-:12])=[O:11])[C:3]=1[O:13][CH3:14]

참가 물질

5

반응물 3

HCID 807IodineHCID 14923Ammonium HydroxideHCID 96959Benzaldehyde, 4-hydroxy-3-methoxy-2-nitro-

생성물 1

HCID 70592654-hydroxy-3-methoxy-2-nitrobenzonitrile

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

4-Hydroxy-3-methoxy-2-nitrobenzaldehyde (200 g, 1.01 mol) was dissolved in THF (2.5 L) and then ammonium hydroxide (2.5 L) was added followed by iodine (464 g, 1.8 mol).

출처 및 근거

ORD 기록
ord-a638210d2e6c4c1296028b718b48653d
출처 데이터셋
uspto-grants-2013_06
특허 번호
US08466283B2

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