tert-Butyl carbazate → 5-Methyl-2-furohydrazide

HRID 1259872

반응식

HRID 1259872 반응식
C(OC(C)(C)C)(=O)[NH:2][NH2:3].[CH3:10][C:11]1[O:15][C:14]([C:16](Cl)=[O:17])=[CH:13][CH:12]=1>C(Cl)Cl>[CH3:10][C:11]1[O:15][C:14]([C:16]([NH:2][NH2:3])=[O:17])=[CH:13][CH:12]=1

참가 물질

4

반응물 2

HCID 70091tert-Butyl carbazateHCID 27598515-Methylfuran-2-carbonyl chloride

생성물 1

HCID 41592505-Methyl-2-furohydrazide

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Tert-butyl carbazate (549 mg, 4.15 mmol) was added to a methylene chloride (10 mL) solution of commercially available 5-methylfuran-2-carbonyl chloride (500 mg, 3.46 mmol) under ice cooling, and the mixture was stirred at room temperature for 1 hour. The reaction solution was concentrated, and then, the residue was dissolved in methylene chloride (10 mL). To the solution, trifluoroacetic acid (2 mL) was added, and the mixture was stirred at room temperature for 1.5 hours. The reaction solution was concentrated to obtain 5-methylfuran-2-carbohydrazide.

후처리

  1. concentrationThe reaction solution was concentrated
  2. dissolutionthe residue was dissolved in methylene chloride (10 mL)
  3. additionTo the solution, trifluoroacetic acid (2 mL) was added
  4. stirringthe mixture was stirred at room temperature for 1.5 hours
  5. concentrationThe reaction solution was concentrated

출처 및 근거

ORD 기록
ord-694b64273cac4806be76eab314deb09a
출처 데이터셋
uspto-grants-2013_06
특허 번호
US08466290B2

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