Triethylamine → 2-(2-Thienyl)ethyl methanesulphonate

HRID 1259967

반응식

HRID 1259967 반응식
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][CH2:7][OH:8].C(N(CC)CC)C.[CH3:16][S:17](Cl)(=[O:19])=[O:18].C(=O)([O-])O.[Na+]>O1CCCC1>[CH3:16][S:17]([O:8][CH2:7][CH2:6][C:2]1[S:1][CH:5]=[CH:4][CH:3]=1)(=[O:19])=[O:18]

참가 물질

6

반응물 4

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 794002-ThiopheneethanolHCID 516892Sodium Bicarbonate

생성물 1

HCID 30477232-(2-Thienyl)ethyl methanesulphonate

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

2-(Thiophen-2-yl)ethanol (1.05 g) was dissolved in tetrahydrofuran (25 ml), triethylamine (1.63 ml) and methanesulfonyl chloride (725 μl) were added and the mixture was stirred for 20 min. Saturated aqueous sodium hydrogen carbonate (50 ml) was added to the reaction mixture, and the mixture was extracted with diisopropyl ether. The extract was washed with saturated brine, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure to give the object product (1.62 g).

후처리

  1. extractionthe mixture was extracted with diisopropyl ether
  2. washThe extract was washed with saturated brine
  3. dry with materialdried over anhydrous magnesium sulfate
  4. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-d9a50b18c9cc404489504edb2be60d4b
출처 데이터셋
uspto-grants-2013_06
특허 번호
US08466282B2

연결된 노트

불러오는 중…