Hydrazine → tert-Butyl 3-(hydrazinecarbonyl)pyrrolidine-1-carboxylate

HRID 1260286노트

반응식

HRID 1260286 반응식
C[C:2]1([C:14]([O-:16])=O)[CH2:6][CH2:5][N:4]([C:7]([O:9][C:10]([CH3:13])([CH3:12])[CH3:11])=[O:8])[CH2:3]1.[NH2:17][NH2:18]>C(O)C>[NH:17]([C:14]([CH:2]1[CH2:6][CH2:5][N:4]([C:7]([O:9][C:10]([CH3:13])([CH3:12])[CH3:11])=[O:8])[CH2:3]1)=[O:16])[NH2:18]

참가 물질

4

반응물 2

HCID 9321HydrazineHCID 713021051-Tert-butyl 3-methylpyrrolidine-1,3-dicarboxylate

생성물 1

HCID 4621605tert-Butyl 3-(hydrazinecarbonyl)pyrrolidine-1-carboxylate

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A solution of 1-tert-butyl 3-methylpyrrolidine-1,3-dicarboxylate (1.00 equiv.) and hydrazine (excess of 50% aq. solution) in ethanol (0.2 M final conc.) is heated to reflux. After the reaction is deemed complete, the reaction mixture is cooled to rt and partially concentrated. The resulting mixture is diluted with EtOAc, and the resulting organics are washed with water and brine, dried (sodium sulfate) and concentrated in vacuo to afford the title compound i-12a.

후처리

  1. concentrationpartially concentrated
  2. additionThe resulting mixture is diluted with EtOAc
  3. washthe resulting organics are washed with water and brine
  4. dry with materialdried (sodium sulfate)
  5. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-475c15a422bb48de9c3a67e81c75ad45
출처 데이터셋
uspto-grants-2013_06
특허 번호
US08470819B2

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