Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → 1-Phenylpyrazol-5-ylamine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Ammonium Hydroxide | HCID 14923 | — |
| 반응물 | Ethyl 5-amino-1-phenyl-1H-pyrazole-4-carboxylate | HCID 85270 | — |
| 생성물 | 1-Phenylpyrazol-5-ylamine | HCID 70006 | 94% |
반응 단계
5-Amino-4-carbethoxy-1-phenylpyrazole (1 eq.) was dissolved in 36% HCl solution (30 eq.) and the reaction mixture was stirred under reflux for overnight. The mixture was cooled, poured onto ice and made basic with NH4OH. The mixture was extracted with DCM (×3). The combined organic fractions were washed with brine, dried (Na2SO4), and the solvent was evaporated under reduced pressure to obtain the product as pale yellow oil in 94% yield. MS (ES+) C9H9N3 requires 159, found: 160 (M+H)+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08470823B2 |
| 출처 데이터셋 | uspto-grants-2013_06 |
| ORD ID | ord-e2f183bfde9840139d413b9b940b96d3 |
| 출처 메모 | uspto-grants-2013_06 |