(Bromomethyl)cyclobutane → N-{3-[4-(5-Cyclobutylmethoxypyridin-2-yloxy)phenyl]-1-methylpropyl}acetamide

반응식

[OH:1][C:2]1[CH:3]=[CH:4][C:5]([O:8][C:9]2[CH:14]=[CH:13][C:12]([CH2:15][CH2:16][CH:17]([NH:19][C:20](=[O:22])[CH3:21])[CH3:18])=[CH:11][CH:10]=2)=[N:6][CH:7]=1.Br[CH2:24][CH:25]1[CH2:28][CH2:27][CH2:26]1>>[CH:25]1([CH2:24][O:1][C:2]2[CH:3]=[CH:4][C:5]([O:8][C:9]3[CH:14]=[CH:13][C:12]([CH2:15][CH2:16][CH:17]([NH:19][C:20](=[O:22])[CH3:21])[CH3:18])=[CH:11][CH:10]=3)=[N:6][CH:7]=2)[CH2:28][CH2:27][CH2:26]1

참가 물질

반응물 2

HCID 2734658(Bromomethyl)cyclobutane

HCID 67302795N-{3-[4-(5-Hydroxypyridin-2-yloxy)phenyl]-1-methylpropyl}acetamide

생성물 1

HCID 44608462N-{3-[4-(5-Cyclobutylmethoxypyridin-2-yloxy)phenyl]-1-methylpropyl}acetamide

실험 절차

N-{3-[4-(5-Hydroxypyridin-2-yloxy)phenyl]-1-methylpropyl}acetamide was reacted with bromomethylcyclobutane in analogy to example 10b.

출처 및 근거

ORD 기록: ord-3ab3bebe503c4a87a39c0f0953539aeb
출처 데이터셋: uspto-grants-2013_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08470841B2

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