Potassium Carbonate → (+/-)-2-Cyclopropyl-1-methoxybut-3-yn-2-ol
반응식
C(=O)([O-])[O-].[K+].[K+].[CH:7]1([C:10]([OH:20])([C:14]#[C:15][Si](C)(C)C)[CH2:11][O:12][CH3:13])[CH2:9][CH2:8]1>CO>[CH:7]1([C:10]([OH:20])([C:14]#[CH:15])[CH2:11][O:12][CH3:13])[CH2:9][CH2:8]1참가 물질
4
실험 절차
10.9 mg of potassium carbonate (0.08 mmol) are added to a solution of 1.67 g of (±)-2-cyclopropyl-1-methoxy-4-(trimethylsilyl)but-3-yn-2-ol (7.86 mmol) in methanol, and the mixture is stirred overnight at ambient temperature. The methanol is evaporated off and the residue is taken up with an ethyl acetate/water mixture. The product is extracted 3 times with ethyl acetate and the organic phases are then combined, dried over sodium sulphate, filtered, and concentrated under vacuum. 0.434 g of (±)-2-cyclopropyl-1-methoxybut-3-yn-2-ol is obtained in the form of an oil used without subsequent purification (crude yield=40%).