Methoxyacetic Acid → HCID 178496459, 화합물

반응식

Cl.Cl.Cl.[O:4]1[C:8]2=[C:9]([N:13]3[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][C@H:21]4[CH2:26][CH2:25][C@H:24]([NH2:27])[CH2:23][CH2:22]4)[CH2:15][CH2:14]3)[N:10]=[CH:11][CH:12]=[C:7]2[CH2:6][CH2:5]1.[CH3:28][O:29][CH2:30][C:31](O)=[O:32]>>[O:4]1[C:8]2=[C:9]([N:13]3[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][C@H:21]4[CH2:26][CH2:25][C@H:24]([NH:27][C:31](=[O:32])[CH2:30][O:29][CH3:28])[CH2:23][CH2:22]4)[CH2:15][CH2:14]3)[N:10]=[CH:11][CH:12]=[C:7]2[CH2:6][CH2:5]1

참가 물질

반응물 2

HCID 12251Methoxyacetic Acid

HCID 178478590HCID 178478590, 화합물2회

생성물 1

HCID 178496459HCID 178496459, 화합물

실험 절차

The title compound, white solid (92 mg, 76%), MS (ISP) m/z=403.5 [(M+H)+], mp 126.5° C., was prepared in accordance with the general method of example 6 from trans-4-{2-[4-(2,3-dihydro-furo[2,3-c]pyridin-7-yl)-piperazin-1-yl]-ethyl}-cyclohexylamine trihydrochloride (intermediate B) (132 mg, 0.3 mmol) and methoxy-acetic acid.

출처 및 근거

ORD 기록: ord-da9b6bd4d9c04d72a505d830bc352846
출처 데이터셋: uspto-grants-2013_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08470828B2

반응 노트

불러오는 중…