Ethyl Acetate → 5-Chloro-1-(3-fluoro-5-methylbenzyl)-2-imino-1,2-dihydropyridine-3-carboxamide hydrobromide

HRID 1260880노트

반응식

HRID 1260880 반응식
[NH2:1][C:2]1[N:10]=[CH:9][C:8]([Cl:11])=[CH:7][C:3]=1[C:4]([NH2:6])=[O:5].[Br:12][CH2:13][C:14]1[CH:19]=[C:18]([CH3:20])[CH:17]=[C:16]([F:21])[CH:15]=1.C(OCC)(=O)C>CN(C=O)C>[BrH:12].[Cl:11][C:8]1[CH:7]=[C:3]([C:4]([NH2:6])=[O:5])[C:2](=[NH:1])[N:10]([CH2:13][C:14]2[CH:19]=[C:18]([CH3:20])[CH:17]=[C:16]([F:21])[CH:15]=2)[CH:9]=1

참가 물질

5

반응물 3

HCID 8857Ethyl AcetateHCID 27784513-Fluoro-5-methylbenzyl bromideHCID 668768832-Amino-5-chloronicotinamide

생성물 1

HCID 686616225-Chloro-1-(3-fluoro-5-methylbenzyl)-2-imino-1,2-dihydropyridine-3-carboxamide hydrobromide수율 42.4%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

A solution of 2-amino-5-chloronicotinamide (150 mg) and 1-(bromomethyl)-3-fluoro-5-methylbenzene (270 mg) in DMF (3 ml) was stirred at 100° C. for 24 hr. After cooling to room temperature, ethyl acetate was added, and the precipitated crystals were filtered and recrystallized to give the title compound (139 mg).

후처리

  1. filtrationthe precipitated crystals were filtered
  2. customrecrystallized

출처 및 근거

ORD 기록
ord-eee8f1bdd6fe409ba3a510730a761f4d
출처 데이터셋
uspto-grants-2013_06
특허 번호
US08470859B2

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