1-[2-(trifluoromethyl)phenyl]-1H-imidazole-2-carboxylic acid → N-[(3R,4R)-1-[(1-acetylpiperidin-4-yl)carbonyl]-3-(3,4-dichlorophenyl)piperidin-4-yl]-N-methyl-1-[2-(trifluoromethyl)phenyl]-1H-imidazole-2-carboxamide

HRID 1260956노트

반응식

HRID 1260956 반응식
[C:1]([N:4]1[CH2:9][CH2:8][CH:7]([C:10]([N:12]2[CH2:17][CH2:16][C@@H:15]([NH:18][CH3:19])[C@H:14]([C:20]3[CH:25]=[CH:24][C:23]([Cl:26])=[C:22]([Cl:27])[CH:21]=3)[CH2:13]2)=[O:11])[CH2:6][CH2:5]1)(=[O:3])[CH3:2].[F:28][C:29]([F:45])([F:44])[C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][C:31]=1[N:36]1[CH:40]=[CH:39][N:38]=[C:37]1[C:41]([OH:43])=O>>[C:1]([N:4]1[CH2:5][CH2:6][CH:7]([C:10]([N:12]2[CH2:17][CH2:16][C@@H:15]([N:18]([CH3:19])[C:41]([C:37]3[N:36]([C:31]4[CH:32]=[CH:33][CH:34]=[CH:35][C:30]=4[C:29]([F:28])([F:45])[F:44])[CH:40]=[CH:39][N:38]=3)=[O:43])[C@H:14]([C:20]3[CH:25]=[CH:24][C:23]([Cl:26])=[C:22]([Cl:27])[CH:21]=3)[CH2:13]2)=[O:11])[CH2:8][CH2:9]1)(=[O:3])[CH3:2]

참가 물질

3

반응물 2

HCID 27607571-[2-(trifluoromethyl)phenyl]-1H-imidazole-2-carboxylic acidHCID 57741761(3R*,4R*)-1-[(1-acetylpiperidin-4-yl)carbonyl]-3-(3,4-dichlorophenyl)-N-methylpiperidin-4-amine

생성물 1

HCID 68935740N-[(3R,4R)-1-[(1-acetylpiperidin-4-yl)carbonyl]-3-(3,4-dichlorophenyl)piperidin-4-yl]-N-methyl-1-[2-(trifluoromethyl)phenyl]-1H-imidazole-2-carboxamide

실험 절차

Using the compound obtained in Example 78 and 1-[2-(trifluoromethyl)phenyl]-1H-imidazole-2-carboxylic acid, and by the reaction and purification in the same manner as in Example 3, the title compound was obtained.

후처리

  1. customby the reaction and purification in the same manner as in Example 3

출처 및 근거

ORD 기록
ord-3bc8e19e926648eaa5b4d0e58ac2b758
출처 데이터셋
uspto-grants-2013_06
특허 번호
US08470816B2

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