7-Chlorothieno[3,2-B]pyridine-2-carbonitrile → 7-(2-Fluoro-4-nitrophenoxy)thieno[3,2-b]pyridine-2-carbonitrile

반응식

[F:1][C:2]1[CH:22]=[C:21]([N+:23]([O-:25])=[O:24])[CH:20]=[CH:19][C:3]=1[O:4][C:5]1[CH:10]=[CH:9][N:8]=[C:7]2[CH:11]=[C:12]([C:14]3SC=C[N:18]=3)[S:13][C:6]=12.ClC1C=CN=C2C=C(C#N)SC=12>>[F:1][C:2]1[CH:22]=[C:21]([N+:23]([O-:25])=[O:24])[CH:20]=[CH:19][C:3]=1[O:4][C:5]1[CH:10]=[CH:9][N:8]=[C:7]2[CH:11]=[C:12]([C:14]#[N:18])[S:13][C:6]=12

참가 물질

반응물 2

HCID 222786367-Chlorothieno[3,2-B]pyridine-2-carbonitrile

HCID 594244257-(2-Fluoro-4-nitrophenoxy)-2-(thiazol-2-yl)thieno[3,2-b]pyridine

생성물 1

HCID 594244217-(2-Fluoro-4-nitrophenoxy)thieno[3,2-b]pyridine-2-carbonitrile

실험 절차

Following the procedure described above for the synthesis of compound 11 (example 12, step 3, scheme 2) but substituting compound 10 for compound 126, title compound 127 was obtained as a yellow solid (114 mg, 60% yield). MS (m/z) 316.0 (M+H).

출처 및 근거

ORD 기록: ord-8cea1ed287ad4062825bdbdf9a29b788
출처 데이터셋: uspto-grants-2013_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08470850B2

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