7-(2-Fluoro-4-nitrophenoxy)-1-methyl-1H-pyrrolo[2,3-c]pyridine → Fluoro-4-(1-methyl-1H-pyrrolo[2,3-c]pyridin-7-yloxy)benzenamine

반응식

F[C:2]1[CH:18]=[C:17]([N+:19]([O-])=O)[CH:16]=[CH:15][C:3]=1[O:4][C:5]1[N:6]=[CH:7][CH:8]=[C:9]2[CH:13]=[CH:12][N:11]([CH3:14])[C:10]=12.N1C2=C(OC3C=CC(N)=CC=3[F:39])N=CC=C2C=C1>>[F:39][C:16]1[CH:15]=[C:3]([O:4][C:5]2[N:6]=[CH:7][CH:8]=[C:9]3[CH:13]=[CH:12][N:11]([CH3:14])[C:10]=23)[CH:2]=[CH:18][C:17]=1[NH2:19]

참가 물질

반응물 2

HCID 594246057-(2-Fluoro-4-nitrophenoxy)-1-methyl-1H-pyrrolo[2,3-c]pyridine

HCID 594246294-(1H-Pyrrolo[2,3-c]pyridin-7-yloxy)-3-fluorobenzenamine

생성물 1

HCID 86644588Fluoro-4-(1-methyl-1H-pyrrolo[2,3-c]pyridin-7-yloxy)benzenamine수율 89%

실험 절차

Starting from the compound 264 and following the procedure described above for the synthesis of amine 261 (scheme 59, step 3, example 218), title compound 265 was obtained in 89% yield as an off-white solid. MS (m/z): 258.1(M+H) (found).

출처 및 근거

ORD 기록: ord-e5192f09354d423195caecf79392e4ae
출처 데이터셋: uspto-grants-2013_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08470850B2

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