4-(2-Fluoro-4-nitrophenoxy)-6-(methylsulfinyl)thieno[3,2-d]pyrimidine → N-(3-Fluoro-4-(6-(methylsulfinyl)thieno[3,2-]pyrimidin-4-yloxy)phenyl carbamothioyl)-2-phenylacetamide

HRID 1261350노트

반응식

HRID 1261350 반응식
FC1C=C([N+]([O-])=O)C=CC=1OC1[C:6]2[S:13][C:12]([S:14]([CH3:16])=[O:15])=[CH:11][C:7]=2N=CN=1.[F:24][C:25]1[CH:26]=[C:27]([NH:43][C:44]([NH:46][C:47](=[O:55])[CH2:48][C:49]2[CH:54]=[CH:53][CH:52]=[CH:51][CH:50]=2)=[S:45])[CH:28]=[CH:29][C:30]=1[O:31][C:32]1C2SC(SC)=CC=2[N:35]=[CH:36][N:37]=1>>[F:24][C:25]1[CH:26]=[C:27]([NH:43][C:44]([NH:46][C:47](=[O:55])[CH2:48][C:49]2[CH:50]=[CH:51][CH:52]=[CH:53][CH:54]=2)=[S:45])[CH:28]=[CH:29][C:30]=1[O:31][C:32]1[C:7]2[CH:11]=[C:12]([S:14]([CH3:16])=[O:15])[S:13][C:6]=2[N:35]=[CH:36][N:37]=1

참가 물질

3

반응물 2

HCID 594245544-(2-Fluoro-4-nitrophenoxy)-6-(methylsulfinyl)thieno[3,2-d]pyrimidineHCID 59424579N-(3-Fluoro-4-(6-(methylthio)thieno[3,2-d]pyrimidin-4-yloxy)phenylcarbamothioyl)-2-phenylacetamide

생성물 1

HCID 86644589N-(3-Fluoro-4-(6-(methylsulfinyl)thieno[3,2-]pyrimidin-4-yloxy)phenyl carbamothioyl)-2-phenylacetamide수율 36%

실험 절차

Starting from the compound 285 and following the procedure described above for the synthesis of compound 283 (scheme 64, step 4, example 225), title compound 286 was obtained in 36% yield as an off-white solid. 1H NMR (DMSO-d6) δ (ppm): 12.45(s, 1H), 11.83(s, 1H), 8.80(s, 1H), 8.13(s, 1H), 7.93(dd, 1H, J1=2.3 Hz, J2=10.9 Hz), 7.55 (t, 1H, J=8.6 Hz), 7.48 (m, 1H), 7.34-7.31(m, 4H), 7.28-7.25(m, 1H), 3.81(s, 2H), 3.08(s, 3H). MS (m/z): 501.0(M+H) (found).

출처 및 근거

ORD 기록
ord-83e91753653841f2a4d3ec17950d44d4
출처 데이터셋
uspto-grants-2013_06
특허 번호
US08470850B2

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