HCID 59596828, 화합물 → 2-[3-(3-Fluoro-benzyloxy)-phenyl]-ethylamine

HRID 1261451노트

반응식

HRID 1261451 반응식
C(OC(=O)[NH:7][CH2:8][CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[C:12]([O:16][CH2:17][C:18]2[CH:23]=[CH:22][CH:21]=[C:20]([F:24])[CH:19]=2)[CH:11]=1)(C)(C)C>ClCCl.FC(F)(F)C(O)=O>[F:24][C:20]1[CH:19]=[C:18]([CH:23]=[CH:22][CH:21]=1)[CH2:17][O:16][C:12]1[CH:11]=[C:10]([CH2:9][CH2:8][NH2:7])[CH:15]=[CH:14][CH:13]=1

참가 물질

4

반응물 1

HCID 59596828HCID 59596828, 화합물

생성물 1

HCID 236253522-[3-(3-Fluoro-benzyloxy)-phenyl]-ethylamine

시약·촉매·용매 2

HCID 6344Dichloromethane용매HCID 6422Trifluoroacetic acid용매

실험 절차

A solution of 10.36 g (30 mmol) of [2-[3-(3-fluoro-benzyloxy)-phenyl]-ethyl]-carbamic acid tert-butyl ester in 100 ml of dichloromethane and 15 ml of trifluoroacetic acid was stirred at room temperature overnight. The solvent was removed, a 5% K2CO3 solution in water was added and the product was extracted with ethyl acetate to obtain the title compound in quantitative yield as a sticky oil.

후처리

  1. customThe solvent was removed
  2. additiona 5% K2CO3 solution in water was added
  3. extractionthe product was extracted with ethyl acetate

출처 및 근거

ORD 기록
ord-e1fc7aca87024fd5936bf924372daace
출처 데이터셋
uspto-grants-2013_06
특허 번호
US08470877B2

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