HCID 178457071, 화합물 → Allyl-(1-pyridin-3-yl-allyl)-amine

반응식

[CH:1]([Mg]Cl)=[CH2:2].[N:5]1[CH:10]=[CH:9][CH:8]=[C:7](/[CH:11]=[N:12]/[CH2:13][CH:14]=[CH2:15])[CH:6]=1>>[CH2:13]([NH:12][CH:11]([C:7]1[CH:6]=[N:5][CH:10]=[CH:9][CH:8]=1)[CH:1]=[CH2:2])[CH:14]=[CH2:15]

참가 물질

반응물 2

HCID 178457071HCID 178457071, 화합물

HCID 178461836HCID 178461836, 화합물

생성물 1

HCID 11651226Allyl-(1-pyridin-3-yl-allyl)-amine수율 87%

실험 절차

According to Example 2, vinyl magnesium chloride (1.00 M in THF, 1.10 mL; 1.10 mmol; 1.10 equiv) was reacted with N-[(E)-3-pyridinylmethylidene]-2-propen-1-amine (11) (146 mg; 1.00 mmol) in the presence of LaCl3.2LiCl (0.33 M; 0.30 mL, 0.10 mmol, 0.10 equiv) at room temperature for 1 h. Column chromatographical purification afforded the desired product 12 as colorless oil (151 mg, 87%). The analytical data were found to be in accordance with the literature data.

후처리

customColumn chromatographical purification

출처 및 근거

ORD 기록: ord-877b066ac31f4db2a041f8812d0bec57
출처 데이터셋: uspto-grants-2013_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08470982B2

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