HCID 66711057, 화합물 → HCID 66710798, 화합물

HRID 1262057노트

반응식

HRID 1262057 반응식
NC1C=CC(N2CCC[C@H](C(N3CCN(C)CC3)=O)C2)=CC=1OC.[CH3:25][O:26][C:27]1[CH:28]=[C:29]([N:36]2[CH2:41][CH2:40][CH:39]([N:42]3[CH2:46][CH2:45][C@@H:44]([OH:47])[CH2:43]3)[CH2:38][CH2:37]2)[CH:30]=[CH:31][C:32]=1[N+:33]([O-])=O>>[NH2:33][C:32]1[CH:31]=[CH:30][C:29]([N:36]2[CH2:41][CH2:40][CH:39]([N:42]3[CH2:46][CH2:45][C@@H:44]([OH:47])[CH2:43]3)[CH2:38][CH2:37]2)=[CH:28][C:27]=1[O:26][CH3:25]

참가 물질

3

반응물 2

HCID 66711057HCID 66711057, 화합물HCID 66711468HCID 66711468, 화합물

생성물 1

HCID 66710798HCID 66710798, 화합물

실험 절차

(R)-1-[1-(4-Amino-3-methoxy-phenyl)-piperidin-4-yl]-pyrrolidin-3-ol was prepared in an analogous fashion to [(S)-1-(4-Amino-3-methoxy-phenyl)-piperidin-3-yl]-(4-methyl-piperazin-1-yl)-methanone of Example 460c replacing [(S)-1-(3-Methoxy-4-nitro-phenyl)-piperidin-3-yl]-(4-methyl-piperazin-1-yl)-methanone with (R)-1-[1-(3-Methoxy-4-nitro-phenyl)-piperidin-4-yl]-pyrrolidin-3-ol (180 mg, 99%). LC/MS (E/I+) 292.16 (M+H).

출처 및 근거

ORD 기록
ord-b27e00a68fa14be28f28154d96cad200
출처 데이터셋
uspto-grants-2013_06
특허 번호
US08471005B2

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