8-(3-Methoxy-4-nitrophenyl)-1,4-dioxa-8-azaspiro[4.5]decane → 4-(1,4-Dioxa-8-azaspiro[4.5]decan-8-yl)-2-methoxyaniline

HRID 1262060노트

반응식

HRID 1262060 반응식
NC1C=CC(N2CCC[C@H](C(N3CCN(C)CC3)=O)C2)=CC=1OC.[CH3:25][O:26][C:27]1[CH:28]=[C:29]([N:36]2[CH2:45][CH2:44][C:39]3([O:43][CH2:42][CH2:41][O:40]3)[CH2:38][CH2:37]2)[CH:30]=[CH:31][C:32]=1[N+:33]([O-])=O>>[O:40]1[C:39]2([CH2:44][CH2:45][N:36]([C:29]3[CH:30]=[CH:31][C:32]([NH2:33])=[C:27]([O:26][CH3:25])[CH:28]=3)[CH2:37][CH2:38]2)[O:43][CH2:42][CH2:41]1

참가 물질

3

반응물 2

HCID 574437338-(3-Methoxy-4-nitrophenyl)-1,4-dioxa-8-azaspiro[4.5]decaneHCID 66711468HCID 66711468, 화합물

생성물 1

HCID 574161624-(1,4-Dioxa-8-azaspiro[4.5]decan-8-yl)-2-methoxyaniline

실험 절차

4-(1,4-Dioxa-8-aza-spiro[4.5]dec-8-yl)-2-methoxy-phenylamine was prepared in an analogous fashion to [(S)-1-(4-Amino-3-methoxy-phenyl)-piperidin-3-yl]-(4-methyl-piperazin-1-yl)-methanone of Example 460c replacing [(S)-1-(3-Methoxy-4-nitro-phenyl)-piperidin-3-yl]-(4-methyl-piperazin-1-yl)-methanone with 8-(3-Methoxy-4-nitro-phenyl)-1,4-dioxa-8-aza-spiro[4.5]decane (1.25 g, 93%). LC/MS (E/I+) 265.08 (M+H).

출처 및 근거

ORD 기록
ord-d2700bf4a78a4eb29b189c61446b3f8b
출처 데이터셋
uspto-grants-2013_06
특허 번호
US08471005B2

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