반응식
[CH3:1][C:2]([CH3:24])([CH3:23])[C:3]([NH:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([C:12]2[N:20]3[C:15]([CH:16]=[N:17][C:18](SC)=[N:19]3)=[CH:14][CH:13]=2)[CH:7]=1)=[O:4].CSC1N=CC2=CC=C([C:36]3[CH:37]=[C:38]([NH2:42])[CH:39]=[CH:40][CH:41]=3)N2N=1.C(Cl)Cl.[CH2:46]([N:48](CC)CC)[CH3:47].CC(C)(C)C(Cl)=[O:56]>>[C:46]([NH:48][C:36]1[CH:37]=[C:38]([NH:42][C:18]2[N:17]=[CH:16][C:15]3=[CH:14][CH:13]=[C:12]([C:8]4[CH:7]=[C:6]([NH:5][C:3](=[O:4])[C:2]([CH3:24])([CH3:23])[CH3:1])[CH:11]=[CH:10][CH:9]=4)[N:20]3[N:19]=2)[CH:39]=[CH:40][CH:41]=1)(=[O:56])[CH3:47]참가 물질
6
반응물 5
생성물 1
반응 조건
- 온도
- 0 °C
실험 절차
2,2-Dimethyl-N-[3-(2-methylsulfanyl-pyrrolo[2,1-f][1,2,4]triazin-7-yl)-phenyl]-propionamide. 3-(2-Methylsulfanyl-pyrrolo[2,1-f][1,2,4]triazin-7-yl)-phenylamine (0.200 g, 0.780 mmol) was dissolved in Methylene chloride (10.0 mL, 156 mmol) and cooled to 0° C. Triethylamine (0.130 mL, 0.936 mmol) was added followed by 2,2-Dimethylpropanoyl chloride (0.106 mL, 0.858 mmol). The reaction mixture was allowed to warm to rt. LCMS after 30 min indicated mass of title compound. Reaction mixture was washed with water, dried over MgSO4, filtered, and concentrated. HPLC rt=3.436, purity=90%, LCMS=341.2 (M+H).
후처리
- temperatureto warm to rt
출처 및 근거
- ORD 기록
- ord-8331ea240a1343d298aa48c4930429c6
- 출처 데이터셋
- uspto-grants-2013_06
- 특허 번호
- US08471005B2
연결된 노트
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