(7-Bromo-pyrrolo[2,1-f][1,2,4]triazin-2-yl)-(4-morpholin-4-yl-phenyl)-amine → {7-[4-(1,1-Dioxo-1$1(6)-thiomorpholin-4-ylmethyl)-phenyl]-pyrrolo[2,1-f][1, 2,4]triazin-2-yl}-(4-morpholin-4-yl-phenyl)-amine

HRID 1262188

반응식

HRID 1262188 반응식
Br[C:2]1[N:10]2[C:5]([CH:6]=[N:7][C:8]([NH:11][C:12]3[CH:17]=[CH:16][C:15]([N:18]4[CH2:23][CH2:22][O:21][CH2:20][CH2:19]4)=[CH:14][CH:13]=3)=[N:9]2)=[CH:4][CH:3]=1.B([C:27]1[CH:32]=[CH:31][C:30]([CH2:33][N:34]2[CH2:39][CH2:38][S:37](=[O:41])(=[O:40])[CH2:36][CH2:35]2)=[CH:29][CH:28]=1)(O)O>>[O:41]=[S:37]1(=[O:40])[CH2:38][CH2:39][N:34]([CH2:33][C:30]2[CH:31]=[CH:32][C:27]([C:2]3[N:10]4[C:5]([CH:6]=[N:7][C:8]([NH:11][C:12]5[CH:17]=[CH:16][C:15]([N:18]6[CH2:19][CH2:20][O:21][CH2:22][CH2:23]6)=[CH:14][CH:13]=5)=[N:9]4)=[CH:4][CH:3]=3)=[CH:28][CH:29]=2)[CH2:35][CH2:36]1

참가 물질

3

반응물 2

HCID 54578326(7-Bromo-pyrrolo[2,1-f][1,2,4]triazin-2-yl)-(4-morpholin-4-yl-phenyl)-amineHCID 54970580(4-((1,1-Dioxidothiomorpholino)methyl)phenyl)boronic acid

생성물 1

HCID 67423918{7-[4-(1,1-Dioxo-1$1(6)-thiomorpholin-4-ylmethyl)-phenyl]-pyrrolo[2,1-f][1, 2,4]triazin-2-yl}-(4-morpholin-4-yl-phenyl)-amine

실험 절차

{7-[4-(1,1-Dioxo-1$1(6)-thiomorpholin-4-ylmethyl)-phenyl]-pyrrolo[2,1-f][1,2,4]triazin-2-yl}-(4-morpholin-4-yl-phenyl)-amine was prepared from (7-bromo-pyrrolo[2,1-f][1,2,4]triazin-2-yl)-(4-morpholin-4-yl-phenyl)-amine and 4-[(4-boronophenyl)methyl]-thiomorpholine 1,1-dioxide in an analogous manner to Example 1031b. Product isolated as a yellow solid (36 mg, 24%). m.p.=251-255° C.; LCMS (m/e) 519 (M+H); 1H-NMR (CDCl3, 400 MHz) δ 8.69 (s, 1H), 8.13 (d, 2H, J=7.8 Hz), 7.55 (d, 2H, J=7.4 Hz), 7.42 (d, 2H, J=7.8 Hz), 7.02-6.97 (m, 1H), 6.92 (d, 2H, J=7.0 Hz), 6.85-6.80 (m, 1H), 6.73-6.64 (m, 1H), 3.93-3.85 (m, 4H), 3.73 (s, 2H), 3.17-3.00 (m, 12H).

출처 및 근거

ORD 기록
ord-e3121779bf9e4c16a1c1385b9732defc
출처 데이터셋
uspto-grants-2013_06
특허 번호
US08471005B2

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