Benzene → (2,4-Dimethyl-phenyl)-(4-fluoro-phenyl)-methanone

HRID 1262721노트

반응식

HRID 1262721 반응식
Cl[C:2]1[CH:17]=[CH:16][C:5]([C:6]([C:8]2[CH:13]=[CH:12][C:11]([CH3:14])=[CH:10][C:9]=2[CH3:15])=[O:7])=[CH:4][CH:3]=1.[F-:18].[Cs+].CN1CCCC1=O.C1C=CC=CC=1>O>[F:18][C:2]1[CH:17]=[CH:16][C:5]([C:6]([C:8]2[CH:13]=[CH:12][C:11]([CH3:14])=[CH:10][C:9]=2[CH3:15])=[O:7])=[CH:4][CH:3]=1

참가 물질

6

반응물 4

HCID 241BenzeneHCID 13387N-methyl-2-pyrrolidoneHCID 25953Cesium fluorideHCID 6105854-Chloro-2',4'-dimethylbenzophenone

생성물 1

HCID 10242880(2,4-Dimethyl-phenyl)-(4-fluoro-phenyl)-methanone수율 78%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

To a mixture of 12.2 g (0.05 mols) of 4-chloro-2',4'-dimethylbenzophenone, 12.1 g (0.08 mols) of cesium fluoride and 20 g of N-methylpyrrolidone were 5 ml of benzene added and water in the reaction system was removed together with benzene by azeotropy. The reaction was carried out under nitrogen atmosphere under reflux by heating while stirring for 15 hours. After cooling, the reaction product obtained was poured into 100 ml of water and then, extracted with 50 ml of diethyl ether and further with 50 ml of ether. The extracts together were dried and distilled and thus, 8.9 g of 4-fluoro-2',4'-dimethylbenzophenone were obtained.

후처리

  1. additionadded
  2. customwater in the reaction system was removed together with benzene by azeotropy
  3. temperatureunder reflux
  4. temperatureby heating
  5. temperatureAfter cooling
  6. customthe reaction product obtained
  7. extractionextracted with 50 ml of diethyl ether and further with 50 ml of ether
  8. customThe extracts together were dried
  9. distillationdistilled

출처 및 근거

ORD 기록
ord-88f76edc44844a389177ddba49135135
출처 데이터셋
uspto-grants-1984_06
특허 번호
US04453009

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