Water → 2-Chloro-6-methyl-4-(2,5-dichloro-4-methylmercapto-phenoxy)-pyridine

HRID 1262783노트

반응식

HRID 1262783 반응식
[Cl:1][C:2]1[CH:7]=[C:6]([S:8][CH3:9])[C:5]([Cl:10])=[CH:4][C:3]=1[O-:11].[K+].[Cl:13][C:14]1[CH:19]=[C:18](Cl)[CH:17]=[C:16]([CH3:21])[N:15]=1.O>CN(C)C=O>[Cl:13][C:14]1[CH:19]=[C:18]([O:11][C:3]2[CH:4]=[C:5]([Cl:10])[C:6]([S:8][CH3:9])=[CH:7][C:2]=2[Cl:1])[CH:17]=[C:16]([CH3:21])[N:15]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 119590832,4-Dichloro-6-methylpyridineHCID 70505068Potassium 2,5-dichloro-4-methylmercapto-phenolate

생성물 1

HCID 130736682-Chloro-6-methyl-4-(2,5-dichloro-4-methylmercapto-phenoxy)-pyridine

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

A solution of 25.5 gm (0.1 mol) of potassium 2,5-dichloro-4-methylmercapto-phenolate and 16.2 gm (0.1 mol) of 2,4-dichloro-6-methyl-pyridine in 100 ml of dimethylformamide was heated under reflux for 5 hours. It was then cooled and poured into 300 ml of water. The precipitate which separated out was recovered by suction filtration, washed with water, and recrystallized from isopropanol.

후처리

  1. temperatureunder reflux for 5 hours
  2. temperatureIt was then cooled
  3. customThe precipitate which separated out
  4. filtrationwas recovered by suction filtration
  5. washwashed with water
  6. customrecrystallized from isopropanol

출처 및 근거

ORD 기록
ord-e9c59a82f7d346e99ef65f079b634475
출처 데이터셋
uspto-grants-1984_06
특허 번호
US04453972

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