Alloxan → 5-(3-benzo[b]furyl)-5-hydroxy-2,4,6(1H,3H,5H)pyrimidinetrione

HRID 1262944

반응식

HRID 1262944 반응식
Br[C:2]1[C:3]2[CH:10]=[CH:9][CH:8]=[CH:7][C:4]=2[O:5][CH:6]=1.C([Li])CCC.[NH:16]1[C:24](=[O:25])[C:22](=[O:23])[C:20](=[O:21])[NH:19][C:17]1=[O:18]>>[O:5]1[CH:6]=[C:2]([C:22]2([OH:23])[C:20](=[O:21])[NH:19][C:17](=[O:18])[NH:16][C:24]2=[O:25])[C:3]2[CH:10]=[CH:9][CH:8]=[CH:7][C:4]1=2

참가 물질

4

반응물 3

HCID 5781AlloxanHCID 6405893-Bromo-1-benzofuranHCID 178418339Butyllithium

생성물 1

HCID 204564705-(3-benzo[b]furyl)-5-hydroxy-2,4,6(1H,3H,5H)pyrimidinetrione

실험 절차

3-Bromobenzo[b]furan [Mason et al., J. Chem. Soc., p. 3150 (1931)] is reacted with n-butyl lithium and then with alloxan, following the procedure of Example 5, to yield 5-(3-benzo[b]furyl)-5-hydroxy-2,4,6(1H,3H,5H)pyrimidinetrione.

출처 및 근거

ORD 기록
ord-5f3eda66791941028ad6cd7b75a514d3
출처 데이터셋
uspto-grants-1984_06
특허 번호
US04454320

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