Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Pyridine → 6-[alpha-(beta-Chloropropanamido)acetamido]-2,4-dichloro-3-methylphenol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Pyridine | HCID 1049 | — |
| 반응물 | Thionyl Chloride | HCID 24386 | — |
| 반응물 | 6-Amino-2,4-dichloro-m-cresol hydrochloride | HCID 170223 | — |
| 반응물 | N-(2-Chloropropanoyl)glycine | HCID 20455717 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | 6-[alpha-(beta-Chloropropanamido)acetamido]-2,4-dichloro-3-methylphenol | HCID 20455716 | 92.2% |
반응 단계
To a mixture composed of 158 g (0.96 mol) of N-(β-chloropropanoyl)glycine thus obtained and 92 g (0.4 mol) of 6-amino-2,4-dichloro-3-methylphenol hydrochloride were added 228 ml (2.88 mol) of pyridine and 2 liters of acetonitrile and stirred under cooling. To the solution was added dropwise 95.2 g (0.8 mol) of thionyl chloride. After the completion of the reaction, water was added to the reaction solution and the crystals thus deposited were collected by filtration and recrystallized from acetonitrile to obtain 125.2 g of 6-[α-(β-chloropropanamido)acetamido]-2,4-dichloro-3-methylphenol.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04455366 |
| 출처 데이터셋 | uspto-grants-1984_06 |
| ORD ID | ord-5acdb209e07c4f12aa06d379c57af99f |
| 출처 메모 | uspto-grants-1984_06 |