m-Chloroperbenzoic acid → 5-(Oxiran-2-yl)pentan-1-ol

HRID 1263273노트

반응식

HRID 1263273 반응식
[CH2:1]([OH:8])[CH2:2][CH2:3][CH2:4][CH2:5][CH:6]=[CH2:7].ClC1C=CC=C(C(OO)=[O:17])C=1>C(Cl)Cl.CCOCC>[O:8]1[CH2:1][CH:2]1[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][OH:17]

참가 물질

5

반응물 2

HCID 70297m-Chloroperbenzoic acidHCID 543123Hept-6-en-1-ol

생성물 1

HCID 136166735-(Oxiran-2-yl)pentan-1-ol수율 105%

시약·촉매·용매 2

HCID 3283Diethyl Ether용매HCID 6344Dichloromethane용매

실험 절차

A mixture of 3 (1.4 g, 12 mmol) and m-chloroperbenzoic acid (2.92 g, 14.4 mmol) in methylene chloride (40 mL) was stirred at room temperature overnight. It was then diluted with ether, washed with saturated aqueous sodium bicarbonate, saturated aqueous sodium chloride, and dried over magnesium sulfate. Removal of the solvent afforded 1.64 g of the crude 6,7-epoxy-1-heptanol (5).

후처리

  1. washwashed with saturated aqueous sodium bicarbonate, saturated aqueous sodium chloride
  2. dry with materialdried over magnesium sulfate
  3. customRemoval of the solvent

출처 및 근거

ORD 기록
ord-5c79409ac5024472978391eca0fc0b90
출처 데이터셋
uspto-grants-1984_06
특허 번호
US04456613

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