Potassium Bromide → 7-Bromo-6-hydroxy-1-heptanol

HRID 1263274노트

반응식

HRID 1263274 반응식
[O:1]1[CH2:9][CH:2]1[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][OH:8].[Br-:10].[K+].C(=O)(O)[O-].[Na+]>C(O)(=O)C.O1CCCC1.CCOCC>[Br:10][CH2:9][CH:2]([OH:1])[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][OH:8]

참가 물질

6

반응물 3

HCID 253877Potassium BromideHCID 516892Sodium BicarbonateHCID 136166735-(Oxiran-2-yl)pentan-1-ol

생성물 1

HCID 133660747-Bromo-6-hydroxy-1-heptanol

시약·촉매·용매 2

HCID 3283Diethyl Ether용매HCID 23444217Acetic acid tetrahydrofuran용매

실험 절차

A mixture of 5 (120 mg, 0.9 mmol) in acetic acid-tetrahydrofuran (2 mL-0.4 mL) was treated with 0.3 mL of saturated aqueous potassium bromide solution at room temperature over 67 hours. It was then diluted with ether and poured into saturated aqueous sodium bicarbonate. The separated organic layer was washed with saturated sodium thiosulfite, saturated sodium chloride, and dried over magnesium sulfate. Evaporation of the solvent gave 127 mg of 7-bromo-6-hydroxy-1-heptanol (4).

후처리

  1. washThe separated organic layer was washed with saturated sodium thiosulfite, saturated sodium chloride
  2. dry with materialdried over magnesium sulfate
  3. customEvaporation of the solvent

출처 및 근거

ORD 기록
ord-e55ae0ea8bc44e1187f5e1d9052070fc
출처 데이터셋
uspto-grants-1984_06
특허 번호
US04456613

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