Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethylene Glycol → Ethyl 1,4-dioxaspiro(4.5)decane-8-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethylene Glycol | HCID 174 | — |
| 반응물 | Diethyl Ether | HCID 3283 | — |
| 반응물 | p-Toluenesulfonic acid | HCID 6101 | — |
| 반응물 | Ethyl 4-oxocyclohexanecarboxylate | HCID 317638 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | Ethyl 1,4-dioxaspiro(4.5)decane-8-carboxylate | HCID 10488810 | — |
반응 단계
4-oxo-cyclohexanecarboxylic acid ethyl ester (52.8 g, 0.31 mole, Merck, Order No. 814249), ethylene glycol (67.4 g, 1.08 mole) and p-toluenesulfonic acid (0.7 g) in toluene (160 ml) were stirred for 20 hours at RT, and the reaction solution was poured into diethyl ether (300 ml) and washed with water, sodium hydrogen carbonate solution and sodium chloride solution. The solution was dried (Na2SO4), concentrated by evaporation in vacuo, and the remaining colorless liquid was processed further without purification.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07728028B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-cf51c88887784dd4a140c68d1eeaed7a |
| 출처 메모 | uspto-grants-2010_06 |