HCID 18617480, 화합물 → HCID 18617845, 화합물

HRID 1264213노트

반응식

HRID 1264213 반응식
[O:1]1C=CC=[C:2]1[C:6]1[CH:11]=[CH:10][C:9]([C:12]([CH3:17])([CH3:16])[C:13]([NH2:15])=[O:14])=[CH:8][CH:7]=1.CC#N.C(Cl)(Cl)(Cl)Cl.[OH2:26]>C(OCC)(=O)C>[C:2]([C:6]1[CH:11]=[CH:10][C:9]([C:12]([CH3:17])([CH3:16])[C:13]([NH2:15])=[O:14])=[CH:8][CH:7]=1)([OH:1])=[O:26]

참가 물질

4

반응물 2

HCID 18617480HCID 18617480, 화합물HCID 22592919water acetonitrile CCl4

생성물 1

HCID 18617845HCID 18617845, 화합물

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

To a solution of 2-(4-(furan-2-yl)-phenyl)-2-methyl-propionamide (reference example 26) (124 mg, 0.5 mmol) in CH3CN/CCl4/H2O (7 mL, 2/2/3) is added NaIO4 (420 mg, 2 mmol) followed by RuCl3 (H2O)(3 mg). The resulting mixture is stirred vigorously for 1.5 h, then diluted with ethyl acetate, washed with water and brine, dried over MgSO4 and concentrated to give 100 mg of the title compound as an orange solid. 1H NMR (CD3OD) d 1.58 (s, 6H), 7.50 (d, J=8 Hz, 2H), 7.98 (d, J=8 Hz, 2H). MS (EI) m/z 208 (M+H).

후처리

  1. washwashed with water and brine
  2. dry with materialdried over MgSO4
  3. concentrationconcentrated

출처 및 근거

ORD 기록
ord-0de5536d44ec4a26ab90c97a182724fb
출처 데이터셋
uspto-grants-2003_04
특허 번호
US06541505B1

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