Dimethylformamide → HCID 18617480, 화합물

HRID 1264214노트

반응식

HRID 1264214 반응식
[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[CH:11]=[CH:10][C:9]([C:12]([CH3:17])([CH3:16])[C:13](O)=[O:14])=[CH:8][CH:7]=1.C[N:19](C=O)C.C(Cl)(=O)C(Cl)=O>C(Cl)Cl>[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[CH:11]=[CH:10][C:9]([C:12]([CH3:17])([CH3:16])[C:13]([NH2:19])=[O:14])=[CH:8][CH:7]=1

참가 물질

5

반응물 3

HCID 6228DimethylformamideHCID 65578Oxalyl chlorideHCID 18182605HCID 18182605, 화합물

생성물 1

HCID 18617480HCID 18617480, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of 2-(4-(furan-2-yl)-phenyl)-2-methyl-propionic Acid (reference example 28) (115 mg, 0.5 mmol) in CH2Cl2 (3 mL) is added DMF (10 mL) followed by oxalyl chloride (0.3 mL, 2M in CH2Cl2). The resulting solution is stirred for 2.5 hours then concentrated. The residue is taken up in methanolic ammonia (7N) and stirred for 14.5 hours, then concentrated to give 124 mg of the title compound as a tan solid. 1H NMR (CDCl3) d 1.58 (s, 6H), 5.2 (bs, 1H), 5.3 (bs, 1H), 6.45 (dd, J=3, 1 Hz, 1H), 6.63 (m, 1H), 7.39 (m, 2H), 7.45 (bs, 1H), 7.65 (m, 2H). MS (EI), m/z 229 (M+).

후처리

  1. concentrationthen concentrated
  2. stirringstirred for 14.5 hours
  3. concentrationconcentrated

출처 및 근거

ORD 기록
ord-b60d892547674fd7aab5e931bcdf93f0
출처 데이터셋
uspto-grants-2003_04
특허 번호
US06541505B1

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