5-(Dimethylamino)pentanenitrile → 5-(Dimethylamino)amylamine

HRID 1264297노트

반응식

HRID 1264297 반응식
[H-].[Al+3].[Li+].[H-].[H-].[H-].[CH3:7][N:8]([CH3:15])[CH2:9][CH2:10][CH2:11][CH2:12][C:13]#[N:14]>CCOCC>[CH3:7][N:8]([CH3:15])[CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][NH2:14]

참가 물질

4

반응물 2

HCID 53056495-(Dimethylamino)pentanenitrileHCID 21226445Aluminium lithium hydride

생성물 1

HCID 34659255-(Dimethylamino)amylamine

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

반응 조건

온도
0 °C

실험 절차

To a cooled (0° C.) solution of lithium aluminum hydride (8 ml, 0.5M in ether) is added, slowly, a solution of 5-(dimethylamino)-pentanenitrile (126 mg, 1 mmol, reference example 94a) in ether (1 mL). On complete addition, the cold bath is removed and stirring continued for 2 h. The reaction mixture is then cooled to 0° C. and quenched by dropwise addition of water (160 mL), sodium hydroxide solution (160 mL, 5M), then a further portion of water (160 mL). The resulting mixture is filtered through celite and the filtrate concentrated under reduced pressure to give an oil which is used without further purification.

후처리

  1. additionis added
  2. additionOn complete addition
  3. customthe cold bath is removed
  4. customquenched by dropwise addition of water (160 mL), sodium hydroxide solution (160 mL, 5M)
  5. filtrationThe resulting mixture is filtered through celite
  6. concentrationthe filtrate concentrated under reduced pressure
  7. customto give an oil which
  8. customis used without further purification

출처 및 근거

ORD 기록
ord-2fc9aaaf4972498191a4e8b350251896
출처 데이터셋
uspto-grants-2003_04
특허 번호
US06541505B1

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