Thionyl Chloride → 2,4-Dichloro-3-cyano-5-fluorobenzoyl chloride

HRID 1264335노트

반응식

HRID 1264335 반응식
S(Cl)(Cl)=O.[C:5]([C:7]1[C:8]([Cl:18])=[C:9]([CH:13]=[C:14]([F:17])[C:15]=1[Cl:16])[C:10](O)=[O:11])#[N:6].[ClH:19].S(=O)=O>N1C=CC=CC=1>[C:5]([C:7]1[C:8]([Cl:18])=[C:9]([CH:13]=[C:14]([F:17])[C:15]=1[Cl:16])[C:10]([Cl:19])=[O:11])#[N:6]

참가 물질

5

반응물 3

HCID 24386Thionyl ChlorideHCID 109005412,4-Dichloro-3-cyano-5-fluorobenzoic acidHCID 22338718Hydrogen chloride sulphur dioxide

생성물 1

HCID 143001312,4-Dichloro-3-cyano-5-fluorobenzoyl chloride수율 95.7%

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

4100 ml of thionyl chloride and 41 ml of pyridine were introduced into a stirred apparatus fitted with metering device and gas outlet leading to a scrubber via a reflux condenser, and, at 20° C., 2050 g of 3-cyano-2,4-dichloro-5-fluorobenzoic acid (99.5% strength) were introduced at the rate of hydrogen chloride/sulphur dioxide evolution. At the end of the addition, the mixture was heated to reflux until the evolution of gas ceased. The mixture was then distilled. In the boiling range from 142 to 145° C./10 mbar, 2150 g (95.7% of theory) of 3-cyano-2,4-dichloro-5-fluorobenzoyl chloride were obtained (content according to GC: 98.0%).

후처리

  1. customfitted with metering device and gas outlet
  2. customleading to a scrubber via a reflux condenser
  3. additionAt the end of the addition
  4. temperaturethe mixture was heated
  5. temperatureto reflux until the evolution of gas
  6. distillationThe mixture was then distilled

출처 및 근거

ORD 기록
ord-03199c8032fe4d1caa078896646bb181
출처 데이터셋
uspto-grants-2003_04
특허 번호
US06541675B2

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