Methanol → Methyl 5-chloro-2,3-dihydroxybenzoate

HRID 1264650노트

반응식

HRID 1264650 반응식
S(=O)(=O)(O)O.[Cl:6][C:7]1[CH:8]=[C:9]([OH:17])[C:10]([OH:16])=[C:11]([CH:15]=1)[C:12]([OH:14])=[O:13].[CH3:18]O>>[Cl:6][C:7]1[CH:8]=[C:9]([OH:17])[C:10]([OH:16])=[C:11]([CH:15]=1)[C:12]([O:14][CH3:18])=[O:13]

참가 물질

4

반응물 3

HCID 887MethanolHCID 1118Sulfuric AcidHCID 123948825-Chloro-2,3-dihydroxybenzoic acid

생성물 1

HCID 18613685Methyl 5-chloro-2,3-dihydroxybenzoate

실험 절차

A mixture of methanol (60 ml) and sulfuric acid (5.2 ml) was stirred at room temperature. 5-Chloro-2,3-dihydroxybenzoic acid (0.11 mol) was added. The reaction mixture was stirred and refluxed for 20 hours, and then poured out onto ice. The precipitate was filtered off, washed with water, and dried, yielding 18.48 g of methyl 5-chloro-2,3-dihydroxybenzoate (intermediate 9; mp: 102° C.).

후처리

  1. stirringThe reaction mixture was stirred
  2. temperaturerefluxed for 20 hours
  3. additionpoured out onto ice
  4. filtrationThe precipitate was filtered off
  5. washwashed with water
  6. customdried

출처 및 근거

ORD 기록
ord-70915e134a844ed1b78dfc4e36e9fbde
출처 데이터셋
uspto-grants-2003_04
특허 번호
US06544997B1

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