4-Chlorobenzoyl chloride → HCID 18613846, 화합물

HRID 1264916노트

반응식

HRID 1264916 반응식
Cl.[NH2:2][CH2:3][C:4]([C:6]1[CH:16]=[CH:15][C:9]([C:10]([O:12][CH2:13][CH3:14])=[O:11])=[CH:8][CH:7]=1)=[O:5].[Cl:17][C:18]1[CH:26]=[CH:25][C:21]([C:22](Cl)=[O:23])=[CH:20][CH:19]=1>>[Cl:17][C:18]1[CH:26]=[CH:25][C:21]([C:22]([NH:2][CH2:3][C:4]([C:6]2[CH:16]=[CH:15][C:9]([C:10]([O:12][CH2:13][CH3:14])=[O:11])=[CH:8][CH:7]=2)=[O:5])=[O:23])=[CH:20][CH:19]=1

참가 물질

3

반응물 2

HCID 85014-Chlorobenzoyl chlorideHCID 18613865193813-77-3

생성물 1

HCID 18613846HCID 18613846, 화합물수율 54%

실험 절차

In the same manner as in Reference Example 6, ethyl 4-(2-amino-1-oxoethyl)benzoate hydrochloride and 4-chlorobenzoyl chloride were condensed to obtain ethyl 4-[2-(4-chlorobenzoylamino)-1-oxoethyl]benzoate. Yield: 54%. NMR (CDCl3) δ 1.41 (3H, t, J=7 Hz), 4.43 (2H, q, J=7 Hz), 4.99 (2H, d, J=4 Hz), 7.23 (1H, brs), 7.46 (2H, d, J=8.5 Hz), 7.84 (2H, d, J=8.5 Hz), 8.09 (2H, d, J=8.5 Hz), 8.21 (2H, d, J=8.5 Hz).

후처리

  1. customcondensed

출처 및 근거

ORD 기록
ord-dadd132d56bb4667a619eda50db24161
출처 데이터셋
uspto-grants-2003_04
특허 번호
US06545009B1

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