Benzoic acid, 3-(aminocarbonyl)-, methyl ester → HCID 15491314, 화합물

반응식

[C:1]([C:4]1[CH:5]=[C:6]([CH:11]=[CH:12][CH:13]=1)[C:7]([O:9][CH3:10])=[O:8])(=[O:3])[NH2:2].[F:14][C:15]([F:27])([F:26])[C:16]1[CH:25]=[CH:24][C:19]([C:20](=O)[CH2:21]Br)=[CH:18][CH:17]=1>>[F:14][C:15]([F:26])([F:27])[C:16]1[CH:17]=[CH:18][C:19]([C:20]2[N:2]=[C:1]([C:4]3[CH:5]=[C:6]([CH:11]=[CH:12][CH:13]=3)[C:7]([O:9][CH3:10])=[O:8])[O:3][CH:21]=2)=[CH:24][CH:25]=1

참가 물질

반응물 2

HCID 184711Benzoic acid, 3-(aminocarbonyl)-, methyl ester

HCID 3219792-Bromo-4'-(trifluoromethyl)acetophenone

생성물 1

HCID 15491314HCID 15491314, 화합물수율 30%

실험 절차

In the same manner as in Example 1, methyl 3-carbamoylbenzoate was reacted with 4-trifluoromethylphenacyl bromide to obtain methyl 3-[4-(4-trifluoromethylphenyl)-2-oxazolyl]benzoate. The product was recrystallized from ethanol. Yield: 30%. Pale yellow prisms. Melting Point: 151 to 152° C.

출처 및 근거

ORD 기록: ord-fc40aa92e2fb4f6ba523ef610b5d645f
출처 데이터셋: uspto-grants-2003_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06545009B1

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