4-Pyridinecarbothioamide → Ethyl 4-[2-(4-pyridyl)-4-thiazolyl)benzoate hydrobromide

반응식

[C:1]([NH2:9])(=[S:8])[C:2]1[CH:7]=[CH:6][N:5]=[CH:4][CH:3]=1.[Br:10][CH2:11][C:12]([C:14]1[CH:24]=[CH:23][C:17]([C:18]([O:20][CH2:21][CH3:22])=[O:19])=[CH:16][CH:15]=1)=O>>[BrH:10].[N:5]1[CH:6]=[CH:7][C:2]([C:1]2[S:8][CH:11]=[C:12]([C:14]3[CH:24]=[CH:23][C:17]([C:18]([O:20][CH2:21][CH3:22])=[O:19])=[CH:16][CH:15]=3)[N:9]=2)=[CH:3][CH:4]=1

참가 물질

반응물 2

HCID 27237884-Pyridinecarbothioamide

HCID 11966043Ethyl 4-(2-bromoacetyl)benzoate

생성물 1

HCID 18613814Ethyl 4-[2-(4-pyridyl)-4-thiazolyl)benzoate hydrobromide수율 67%

실험 절차

In the same manner as in Example 74, thioisonicotinamide was reacted with ethyl 4-bromoacetylbenzoate to obtain ethyl 4-[2-(4-pyridyl)-4-thiazolyl)benzoate hydrobromide. The product was, recrystallized from ethanol. Yield: 67%. Pale Yellow prisms. Melting point: 247 to 248° C.

출처 및 근거

ORD 기록: ord-2112c5fbc84a471482d1dcee802a2480
출처 데이터셋: uspto-grants-2003_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06545009B1

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