m-Chloroperbenzoic acid → HCID 9801756, 화합물

HRID 1265177노트

반응식

HRID 1265177 반응식
[Cl:1][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[C:4]([Cl:12])[C:3]=1[N:13]1[C:17]([NH:18][C:19](=[O:21])[CH3:20])=[C:16]2[CH2:22][S:23][CH2:24][C:15]2=[N:14]1.C1C=C(Cl)C=C(C(OO)=[O:33])C=1.C([O-])(O)=O.[Na+]>C(Cl)Cl>[Cl:1][C:2]1[CH:7]=[C:6]([C:8]([F:10])([F:11])[F:9])[CH:5]=[C:4]([Cl:12])[C:3]=1[N:13]1[C:17]([NH:18][C:19](=[O:21])[CH3:20])=[C:16]2[CH2:22][S:23](=[O:33])[CH2:24][C:15]2=[N:14]1

참가 물질

5

반응물 3

HCID 70297m-Chloroperbenzoic acidHCID 516892Sodium BicarbonateHCID 9800860HCID 9800860, 화합물

생성물 1

HCID 9801756HCID 9801756, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of acetamide (2) (145 mg, 0.37 mmol) in CH2Cl2 (5 mL), m-CPBA (500 mg) was added. The reaction mixture was stirred at room temperature for 30 min. and aq. NaHCO3 (10 mL) was added and the organic layer separated and washed with water (2×10 mL), dried (Na2SO4) and concentrated to obtain the title compound as a white solid. (35%); 1H NMR (CDCl3) δ 7.8 (2H, m), 4.33 and 4.46 (2H each, m), 2.12 (3H, s); MS (M+) 428.

후처리

  1. customthe organic layer separated
  2. washwashed with water (2×10 mL)
  3. dry with materialdried (Na2SO4)
  4. concentrationconcentrated

출처 및 근거

ORD 기록
ord-1616ba520a78403baf217fd516e62d45
출처 데이터셋
uspto-grants-2003_04
특허 번호
US06545033B1

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