Acetic Acid → 2,5-Di-pyridin-3-yl-pyrrol-1-ylamine

HRID 1265294노트

반응식

HRID 1265294 반응식
C[Si](C)(C)CCOC(=O)[NH:7][N:8]1[C:12]([C:13]2[CH:14]=[N:15][CH:16]=[CH:17][CH:18]=2)=[CH:11][CH:10]=[C:9]1[C:19]1[CH:20]=[N:21][CH:22]=[CH:23][CH:24]=1.CCCC[N+](CCCC)(CCCC)CCCC.[F-].C1COCC1.C(O)(=O)C>C1(C)C=CC=CC=1>[N:15]1[CH:16]=[CH:17][CH:18]=[C:13]([C:12]2[N:8]([NH2:7])[C:9]([C:19]3[CH:20]=[N:21][CH:22]=[CH:23][CH:24]=3)=[CH:10][CH:11]=2)[CH:14]=1

참가 물질

6

반응물 4

HCID 176Acetic AcidHCID 8028TetrahydrofuranHCID 2724141Tetrabutylammonium FluorideHCID 69946665(2,5-Di-pyridin-3-yl-pyrrol-1-yl)-carbamic acid 2-trimethylsilanyl-ethyl ester

생성물 1

HCID 186154692,5-Di-pyridin-3-yl-pyrrol-1-ylamine

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

(2,5-di-pyridin-3-yl-pyrrol-1-yl)-carbamic acid 2-trimethylsilanyl-ethyl ester (1 g, 2.6 mmol) is treated with a 1M solution of TBAF in THF (5.2 ml, 5.2 mmol). The resulting solution is stirred overnight under Ar at rt, then quenched with glacial acetic acid (0.3 ml, 5.2 mmol) and diluted with toluene. The resulting solution is passed through a short plug of silica gel and concentrated in vacuo to afford 2,5-Di-pyridin-3-yl-pyrrol-1-ylamine.

후처리

  1. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-860bc28069ef455db48f07619e7c5e7c
출처 데이터셋
uspto-grants-2003_04
특허 번호
US06545108B1

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