Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → 3-(4-Chloro-6-fluoro-3-methyl-2-nitrophenyl)-methyl-6-trifluoromethyl-2,4(1H, 3H)-pyrimidinedione
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Dimethyl Sulfate | HCID 6497 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 3-(4-chloro-6-fluoro-3-methyl-2-nitrophenyl)-6-trifluoromethyl-2,4(1H, 3H)-pyrimidinedione | HCID 86585901 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 3-(4-Chloro-6-fluoro-3-methyl-2-nitrophenyl)-methyl-6-trifluoromethyl-2,4(1H, 3H)-pyrimidinedione | HCID 56991091 | — |
반응 단계
3-(4-Chloro-6-fluoro-3-methyl-2-nitrophenyl)-6-trifluoromethyl-2,4(1H, 3H)-pyrimidinedione (10.1 g) was dissolved in dimethylformamide (100 ml) and potassium carbonate (5.7 g, 41.3 mmol) and dimethylsulfate (11.9 g, 55.1 mmol) were added. Solution was stirred at ambient temperature for 14 hr, water was added and product extracted with ethyl acetate. The title compound was separated by column chromatography on silica gel (eluent, hexane-ethyl aceatate, 9:1; 8.5 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06545161B2 |
| 출처 데이터셋 | uspto-grants-2003_04 |
| ORD ID | ord-ea8c95a88720467a91cacbee97dd173f |
| 출처 메모 | uspto-grants-2003_04 |