1-Tetralone → (R)-(-)-1,2,3,4-Tetrahydro-1-naphthol
반응식
[CH2:1]1[CH2:11][C:9](=[O:10])[C:8]2[C:3](=[CH:4][CH:5]=[CH:6][CH:7]=2)[CH2:2]1>CC(O)C>[CH2:1]1[CH2:2][C:3]2[C:8](=[CH:7][CH:6]=[CH:5][CH:4]=2)[C@H:9]([OH:10])[CH2:11]1참가 물질
3
반응 조건
- 온도
- 35 °C
실험 절차
Sodium 2-propoxide (0.38 ml of 0.1M solution in 2-propanol) was charged to the catalyst solution followed by the α-tetralone (0.5 ml, 3.76 mmol). The mixture was stirred under vacuum (80 mmHg) at 35° C. for 2 h, after the first hour the flask was back filled with nitrogen and sufficient 2-propanol charged to compensate for the volume removed by distillation. This gave (R)-1-tetralol Yield 98.4%, ee 95.7%. The turnover number, integrated over 1 h, was 185 h−1
후처리
- additioncharged
- customremoved by distillation
출처 및 근거
- ORD 기록
- ord-8acfcadd05e7439cb808001111c7a19c
- 출처 데이터셋
- uspto-grants-2003_04
- 특허 번호
- US06545188B2
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