Stannous chloride dihydrate → Carbamic acid,[2-amino-4-cyano-5-(diethylamino)phenyl]-,1,1-dimethylethyl ester

반응식

[C:1]([O:5][C:6](=[O:24])[NH:7][C:8]1[CH:13]=[C:12]([N:14]([CH2:17][CH3:18])[CH2:15][CH3:16])[C:11]([C:19]#[N:20])=[CH:10][C:9]=1[N+:21]([O-])=O)([CH3:4])([CH3:3])[CH3:2].O.O.Cl[Sn]Cl>>[C:1]([O:5][C:6](=[O:24])[NH:7][C:8]1[CH:13]=[C:12]([N:14]([CH2:17][CH3:18])[CH2:15][CH3:16])[C:11]([C:19]#[N:20])=[CH:10][C:9]=1[NH2:21])([CH3:3])([CH3:4])[CH3:2]

참가 물질

반응물 2

HCID 61436Stannous chloride dihydrate

HCID 69688996(4-Cyano-5-diethylamino-2-nitro-phenyl)-carbamic acid tert-butyl ester

생성물 1

HCID 69688422Carbamic acid,[2-amino-4-cyano-5-(diethylamino)phenyl]-,1,1-dimethylethyl ester

실험 절차

The title compound was prepared from (4-cyano-5-diethylamino-2-nitro-phenyl)-carbamic acid tert-butyl ester (Example C27) (1.66 g, 4.96 mmol) by reduction with SnCl2.2H2O according to the general procedure J (method b). Obtained as an off-white solid (1.38 g, 91%).

출처 및 근거

ORD 기록: ord-c7eeae9211d14f639b984a559e966cd5
출처 데이터셋: uspto-grants-2003_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06544985B2

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