Trifluoroacetic acid → HCID 10115228, 화합물

HRID 1265904노트

반응식

HRID 1265904 반응식
C(OC(=O)[NH:7][C:8]1[CH:13]=[C:12]([N:14]([CH2:16][CH:17]([CH3:19])[CH3:18])[CH3:15])C(C(F)(F)F)=[CH:10][C:9]=1[NH:24][C:25](=[O:40])[CH2:26][C:27](=O)[C:28]1[CH:33]=[CH:32][CH:31]=[C:30]([N:34]2[CH:38]=[CH:37][N:36]=[N:35]2)[CH:29]=1)(C)(C)C.[C:42](O)([C:44]([F:47])([F:46])[F:45])=O>C(Cl)Cl>[CH2:16]([N:14]([CH3:15])[C:12]1[C:42]([C:44]([F:47])([F:46])[F:45])=[CH:10][C:9]2[NH:24][C:25](=[O:40])[CH2:26][C:27]([C:28]3[CH:33]=[CH:32][CH:31]=[C:30]([N:34]4[CH:38]=[CH:37][N:36]=[N:35]4)[CH:29]=3)=[N:7][C:8]=2[CH:13]=1)[CH:17]([CH3:19])[CH3:18]

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 86586903{5-(Isobutyl-methyl-amino)-2-[3-oxo-3-(3-[1,2,3]triazol-1-yl-phenyl)-propionylamino]-4-trifluoromethyl-phenyl}-carbamic acid tert-butyl ester

생성물 1

HCID 10115228HCID 10115228, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

The title compound was prepared from {5-(isobutyl-methyl-amino)-2-[3-oxo-3-(3-[1,2,3]triazol-1-yl-phenyl)-propionylamino]-4-trifluoromethyl-phenyl}-carbamic acid tert-butyl ester (Example M124) (0.44 g, 0.77 mmol) by treatment with TFA in CH2Cl2 according to the general procedure N. Obtained as a light brown solid (170 mg, 49%).

출처 및 근거

ORD 기록
ord-1e02fd919f0f4e4e9bb4a7e7bebdbd38
출처 데이터셋
uspto-grants-2003_04
특허 번호
US06544985B2

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