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llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
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4-Pyridylthiourea → 8-Chloro-7-dimethylamino-4-{3-[2-(pyridin-4-ylamino)-thiazol-4-yl]-phenyl}-1,3-dihydro-benzo[b][1,4]diazepin-2-one

HRID 1265927
노트
인쇄 미리보기

반응식

HRID 1265927 반응식
Br[CH2:2][C:3]([C:5]1[CH:6]=[C:7]([C:11]2[CH2:17][C:16](=[O:18])[NH:15][C:14]3[CH:19]=[C:20]([Cl:26])[C:21]([N:23]([CH3:25])[CH3:24])=[CH:22][C:13]=3[N:12]=2)[CH:8]=[CH:9][CH:10]=1)=O.[N:27]1[CH:32]=[CH:31][C:30]([NH:33][C:34]([NH2:36])=[S:35])=[CH:29][CH:28]=1>C1COCC1.CCOC(C)=O>[Cl:26][C:20]1[C:21]([N:23]([CH3:25])[CH3:24])=[CH:22][C:13]2[N:12]=[C:11]([C:7]3[CH:8]=[CH:9][CH:10]=[C:5]([C:3]4[N:36]=[C:34]([NH:33][C:30]5[CH:31]=[CH:32][N:27]=[CH:28][CH:29]=5)[S:35][CH:2]=4)[CH:6]=3)[CH2:17][C:16](=[O:18])[NH:15][C:14]=2[CH:19]=1
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참가 물질

5

반응물 2

HCID 27372494-PyridylthioureaHCID 186132344-(3-Bromoacetyl-phenyl)-8-chloro-7-dimethylamino-1,3-dihydro-benzo[b][1,4]diazepin-2-one

생성물 1

HCID 186135028-Chloro-7-dimethylamino-4-{3-[2-(pyridin-4-ylamino)-thiazol-4-yl]-phenyl}-1,3-dihydro-benzo[b][1,4]diazepin-2-one수율 37.6%

시약·촉매·용매 2

HCID 8028Tetrahydrofuran용매
HCID 8857
Ethyl Acetate
용매

반응 조건

온도
60 °C

실험 절차

A mixture of 4-(3-bromoacetyl-phenyl)-8-chloro-7-dimethylamino-1,3-dihydro-benzo[b][1,4]diazepin-2-one (130 mg) (Example 193a) and 1-(4-pyridyl)-2-thiourea (46 mg) in THF (3 mL) was heated at 60° C. for 45 min. The mixture was diluted with AcOEt and washed with sat. NaHCO3 solution and with brine. The organic layer was dried and evaporated and the residue was triturated with Et2O to give the title compound (55 mg) as yellow solid.

후처리

  1. washwashed with sat. NaHCO3 solution and with brine
  2. customThe organic layer was dried
  3. customevaporated
  4. customthe residue was triturated with Et2O

출처 및 근거

ORD 기록
ord-38e8eed7f22c4f33860e1d31f22fa009
출처 데이터셋
uspto-grants-2003_04
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US06544985B2

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