Sodium Chloride → Moxifloxacin

HRID 1265944노트

반응식

HRID 1265944 반응식
[CH3:1][O:2][C:3]1[C:8]([N:9]2[CH2:17][C@@H:16]3[C@@H:11]([CH2:12][CH2:13][CH2:14][NH:15]3)[CH2:10]2)=[C:7]([F:18])[CH:6]=[C:5]2[C:19]([C:21]([C:27]([OH:29])=[O:28])=[CH:22][N:23]([CH:24]3[CH2:26][CH2:25]3)[C:4]=12)=[O:20].Cl.[Cl-].[Na+]>O>[CH3:1][O:2][C:3]1[C:8]([N:9]2[CH2:17][C@@H:16]3[C@@H:11]([CH2:12][CH2:13][CH2:14][NH:15]3)[CH2:10]2)=[C:7]([F:18])[CH:6]=[C:5]2[C:19]([C:21]([C:27]([OH:29])=[O:28])=[CH:22][N:23]([CH:24]3[CH2:26][CH2:25]3)[C:4]=12)=[O:20]

참가 물질

4

반응물 2

HCID 5234Sodium ChlorideHCID 101526Moxifloxacin Hydrochloride

생성물 1

HCID 152946Moxifloxacin

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
121 °C

실험 절차

The water is initially charged in a reaction vessel made of glass, and moxifloxacin hydrochloride is dissolved therein with stirring. Sodium chloride is added to the solution of the active compound and dissolved therein. An Fe(III) chloride solution is added to the mixture. The mixture is filtered through a 0.2 μm sterile filter and in each case 250 ml are filled into an infusion bottle which is closed and heated in an autoclave at 121° C. for 20 min.

후처리

  1. dissolutionis dissolved
  2. dissolutiondissolved
  3. filtrationThe mixture is filtered through a 0.2 μm
  4. filtrationsterile filter and in each case 250 ml
  5. additionare filled into an infusion bottle which
  6. customis closed

출처 및 근거

ORD 기록
ord-537fac695b5f47cd9788065522379c4b
출처 데이터셋
uspto-grants-2003_04
특허 번호
US06548079B1

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