HCID 575505, 화합물 → 2-amino-N-(naphthalen-1-yl)benzamide

HRID 1266471노트

반응식

HRID 1266471 반응식
[C:1]1([NH:11][C:12]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[N+:20]([O-])=O)=[O:13])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1>C(O)C.[Pd]>[NH2:20][C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=1[C:12]([NH:11][C:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1)=[O:13]

참가 물질

4

반응물 1

HCID 575505HCID 575505, 화합물

생성물 1

HCID 8519642-amino-N-(naphthalen-1-yl)benzamide

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

To a solution of N-naphthyl(2-nitrophenyl)carboxamide in ethanol was added Pd/C and the mixture was stirred under an atmosphere of hydrogen for 16 hours. Pd/C was removed by filtration and the solvent was evaporated. The resulting oil was dissolved in ethyl acetate and extracted with aqueous HCl. The aqueous layer was neutralized and extracted with ethyl acetate. The organic layer was separated, dried over anhydrous sodium sulfate and concentrated to give (2-aminophenyl)-N-naphthylcarboxamide, a compound of Formula I.

후처리

  1. customPd/C was removed by filtration
  2. customthe solvent was evaporated
  3. dissolutionThe resulting oil was dissolved in ethyl acetate
  4. extractionextracted with aqueous HCl
  5. extractionextracted with ethyl acetate
  6. customThe organic layer was separated
  7. dry with materialdried over anhydrous sodium sulfate
  8. concentrationconcentrated

출처 및 근거

ORD 기록
ord-54040c84f58447f29b1c1e928de9a38a
출처 데이터셋
uspto-grants-2003_04
특허 번호
US06548548B2

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